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* In ''VideoGame/HonkaiStarRail'', the "long-lived" citizens who make up the majority of those living on the [[MobileCity Xianzhou Luofu]] suffer from an affliction known as "Mara-Struck" after they've lived for an extended amount of time; victims who are Mara-Struck suffer from degrading sanity and mutations, eventually becoming violent and irrational and requiring that they be put down before they hurt others. While the actual cause of being Mara-Struck is unknown, the most widely accepted theory is this trope, that the person has so many memories in their heads that it clouds their thoughts, until only the strongest memories (such as those of rage, grief, pain, and hatred) are coherent to the victim, and as such they become obsessed with these memories and emotions alone until it overwhelms them, changing them both mentally and physically.
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%%* This was a plot of a NightmareFuel horror comic from UsefulNotes/TheSilverAgeOfComicBooks. The man gets hit with a [[EvolutionaryLevels evolution-devolution]] ray, and as his head starts to [[MyBrainIsBig evolve and gets bigger]] (in the traditional Future Human way of comics from the time), his body "devolves" to that of a tiny lizard.%%This example has been commented out for not identifying the work from which it originates. Do not uncomment it without adding the work.
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%%* This was a plot of a NightmareFuel horror comic from UsefulNotes/TheSilverAgeOfComicBooks.MediaNotes/TheSilverAgeOfComicBooks. The man gets hit with a [[EvolutionaryLevels evolution-devolution]] ray, and as his head starts to [[MyBrainIsBig evolve and gets bigger]] (in the traditional Future Human way of comics from the time), his body "devolves" to that of a tiny lizard.%%This example has been commented out for not identifying the work from which it originates. Do not uncomment it without adding the work.
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* ''Webcomic/GirlGenius:'' This is one of the dangers facing anyone who attempts to become a second-stage [[MadScientist Spark]]. When protagonist Agatha unwittingly starts down this path, she backtracks by spreading all that excess energy between her, Gil and Tarvek before she "explodes or something." Albia, the immortal God-Queen of England, who has actually done the full procedure, is forced to channel much of her thousands of years of memories into a site seperate from her body.
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this phenomenon is covered under Idiot Savant
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* In ''Film/RainMan'', Raymond is an autistic IdiotSavant who has superhuman memory retention and computational skills, offset by severe social disability; based on a RealLife person.
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* In ''Radiant'' by James Allan Gardner, the "Balrog" hive-mind spore colony infecting Youn Sue's mind grant her wish to see and think as they do... by spreading her mind slowly to absorb more information while retaining the detail of her original perspective. She pleads for them to stop, but they continue until she blacks out from brain damage. The Balrog then moves in and reconstructs the damaged bits to bring her out of her coma.
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* In ''Radiant'' ''[[Literature/TheLeagueOfPeoplesVerse Radiant]]'' by James Allan Alan Gardner, the "Balrog" hive-mind spore colony infecting Youn Sue's mind grant her wish to see and think as they do... by spreading her mind slowly to absorb more information while retaining the detail of her original perspective. She pleads for them to stop, but they continue until she blacks out from brain damage. The Balrog then moves in and reconstructs the damaged bits to bring her out of her coma.
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* ''[[ComicBook/TheTransformersMoreThanMeetsTheEye The Transformers: Lost Light]]'': A glimpse of the future in the final issue shows that Rewind eventually uploads so much information into his mental database that he corrupts his brain and [[ShapeshifterModeLock forgets how to transform]] out of his memory stick mode.
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Compare DeadlyUpgrade and TooMuchForManToHandle. Also compare TheFogOfAges, where an immortal being has been collecting memories for so long that they're overwriting the oldest ones. Not to be confused with MyBrainIsBig, where the skull ''literally'' runneth over and the brain shows outside it, although that trope can manifest as a consequence of this one. See also SuperIntelligence and AMindIsATerribleThingToRead.
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Compare DeadlyUpgrade and TooMuchForManToHandle. Also compare TheFogOfAges, where an immortal being has been collecting memories for so long that they're overwriting the oldest ones. Not to be confused with MyBrainIsBig, where the skull ''literally'' runneth over and the brain shows outside it, although that trope can manifest as a consequence of this one. Nor is it to be confused with TooMuchInformation. See also SuperIntelligence and AMindIsATerribleThingToRead.
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* In "Literature/FlowersForAlgernon", the titular mouse and the intellectually disabled protagonist Charlie Gordon are both given extreme intelligence from an operation. However, [[spoiler:as time goes on, both Algernon and Charlie Gordon start to [[FlowersForAlgernonSyndrome degrade in intelligence]] before finally dying, with any way to stop this from occurring lost when Charlie started losing his intelligence]].
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* In "Literature/FlowersForAlgernon", ''Literature/FlowersForAlgernon'', the titular mouse and the intellectually disabled protagonist Charlie Gordon are both given extreme intelligence from an operation. However, [[spoiler:as time goes on, both Algernon and Charlie Gordon start to [[FlowersForAlgernonSyndrome degrade in intelligence]] before finally dying, with any way to stop this from occurring lost when Charlie started losing his intelligence]].
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* ''ComicBook/TheMightyThor'': Odin briefly does this to [[Franchise/IronMan Iron Man]] at one point, when the latter questions the wisdom of his decisions. He doesn't give Tony enough knowledge to drive him insane or kill him, but just enough of a glimpse of the cosmos to humble him and paralyze him for a while.
